Janssen Research & Development LLC, a Johnson & Johnson company, is recruiting for a Scientist to support the discovery and development of novel therapeutics for chronic kidney diseases. The position is within the Cardiovascular, Metabolism, Retina & Pulmonary Hypertension Discovery Team, and will be based in Spring House PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Scientist will provide scientific and technical support for conducting research involving in vitro and ex vivo preclinical studies that relate to polycystic kidney disease. The qualified scientist needs to independently design and carry out experiments, troubleshoot problems, analyze and interpret data, and communicate findings. The research may encompass a range of pathways underlying the disease pathology, such as epithelial cell proliferation, innate immune responses, stromal cell responses/fibrosis, and vasculature abnormalities. A background in renal biology with a focus on in vitro or in vivo models of kidney disease is a strong plus. Responsibilities include but are not limited to:

Key Responsibilities:

• Develop and apply multiple preclinical in vitro or ex vivo models and cell-based assays to evaluate novel mechanisms or therapies related chronic kidney diseases such as autosomal dominant polycystic kidney disease (ADPKD)
• Execute on research plans as a core member of cross-functional program project teams to support the progression of novel drug candidates into clinical development and beyond
• Collaborate closely with in vivo pharmacology and biomarker teams by providing technical and strategic input, and by generating critical data to support target validation, candidate selection, and to help establish translational pharmacology plans
• Generate and test novel target ideas as a project champion
• Pro-actively investigate, improve or change existing methods and techniques to effectively progress drug discovery programs
• Reliably document, interpret results and data, and present scientific findings within project teams or to upper management to enable decision-making

Qualifications

Education:

• PhD or MD in cell biology, molecular biology, or a related area is required.

Experience and Skills:

Required:

• Post-graduate experience in a related field is required.
• Proven ability to work efficiently in a highly collaborative environment is required.
• Experience with data collection and sample processing is required.
• Highly motivated and a team player, with excellent oral, written, and interpersonal skills is required.

Preferred:

• Deep understanding of kidney-related disease biology is strongly preferred.
• Proven ability to lead projects to address complex biological questions is a plus.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.