Senior Scientist, Assay Development and High-Throughput Screening
Pfizer’s BioMedicine Design (BMD) Assay Development group is seeking a highly motivated scientist with experience in liquid-handling automation to establish binding and functional assays to support hit-to-lead discovery of and antibody and mRNA therapeutics. The candidate will play a critical role in the design and execution of biochemical and of cell-based functional assay and high-throughput screening to support the BioMedicine Design portfolio. The candidate will be responsible for the design and execution of experiments using a variety of detection technologies including HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity. In addition, the candidate will analyze data, present results at internal meetings, and closely collaborate with project team members to develop strategies and identify lead molecules. We are looking for a creative, solution-oriented individual who enjoys the opportunity to explore new methods.
ROLE RESPONSIBILITIES
- Develop assays to identify and characterize antibody and mRNA hits to support programs across multiple therapeutic areas. Biochemical assay formats include binding, competition and enzymatic cleavage assays. Cell based assays include binding, competition, cell signaling (NanoBiT, Ca2+ flux, cAMP, phospho-protein) and reporter gene assays using a variety of cell lines.
- Execute high-throughput screens using automation platforms, including rapid data analysis.
- Collaborate with project teams to establish screening strategies, interpret results, and make decisions to drive programs forward.
- Write protocols, maintain ELN, and regularly review literature to maintain knowledge of scientific trends and new technologies.
BASIC QUALIFICATIONS
- Bachelor’s degree with 9+ years of experience, or master’s degree with 6+ years of experience in molecular biology, biochemistry, cell biology or a related discipline, along with a basic understanding of biologics drug discovery workflows.
- Demonstrated expertise in assay development and troubleshooting with methods such as HTRF, ELISA/DELFIA, FACS, and cell-based functional assays focused on signaling, proliferation, or cytotoxicity.
- At least 6 years of industry experience in high-throughput screening and data analysis
- At least 6 years of experience with using laboratory automation, including writing and troubleshooting protocols
- Track record of strong problem solving and organizational skills, attention to detail, and ability to multi-task
- Strong written and oral communication skills
PREFERRED QUALIFICATIONS
- Experience with Tecan and Beckman liquid handling platforms and Momentum scheduling software
- Experience with high content imaging and multiplex assay formats
- Experience writing scripts to automate data processing
- Experience mentoring junior lab members
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
#LI-PFE
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Research and Development